The evaluation of the thyroid nodule begins with patient history, risk factor assessment, and physical exam. It included all the patients with clinically detected STN who had undergone thyroidectomy between June and May The decision for surgery was based on individual patient’s examination and investigation findings. In our study group, Clin Endocrinol Oxf ; Suresh , 2 and Amarchala Yadagiri Lakshmi 3.

The colloid nodules either observed or suppressed by thyroxin, also surgery is recommended if the nodule grows; only for exclusion of malignancy. When FNAC report was malignant, total thyroidectomy was done. All patients with a thyroid nodule should undergo cervical ultrasonography and have serum TSH measured. Hemithyroidectomy was followed by completion thyroidectomy in 10 6. For all cases, histopathological examination of the corresponding surgical samples, and immunohistochemical analysis of cell block specimens to detect antibody reactivity against Cytokeratin, HBME-1, and Galectin-3 were also performed. Age, gender, history of radiation exposure, family history of thyroid disease, and the thyroid hormone profile.

Support Center Support Center. The most common presentation of STN was as a swelling in the anterior aspect of the neck.

Only 14 pages are availabe for public view. Cell block preparation was non-contributary in 26 out of 61 cases Radioisotope nnodule of the thyroid after a tracer dose of an isotope will show the nodule hot, warm, or cold.

J Indian Med Assoc. All cases diagnosed as carcinoma by FNAC 13 were proved also by histopathological examination to be carcinoma;10 cases were diagnosed as papillary carcinoma, two cases as medullary carcinoma, and one case anaplastic carcinoma.

solitary thyroid nodule thesis

International patterns of cancer incidence in adolescents. The method of solitary thyroid nodule management depends chiefly on the scheme used in the diagnosis and treatment.


If the report was benign, the patient was managed by regular monitoring of hormone levels, thesjs or without thyroid hormone supplementation. Central node dissection was done in all malignant cases with USG showing lymph node enlargement and also in cases with intra operative enlarged nodes. One case was diagnosed as Hurthle cell neoplasm by FNAC and revealed by histopathological examination as Hurthle cell adenoma. Pathology of thyroid nodule.

The majority of STNs are malignant. Total thyroidectomy was done in those cases where FNAC was reported as malignant.

Cell biology and flow cytometry.


For the cystic nodules aspiration is both diagnostic and treatment, with post aspiration observation. What found in sections from the cell block in thyroid FNA observed in this study made this preparation a useful technique for ancillary studies such as immunohistochemistry and molecular tests.

Hemithyroidectomy was performed for patients showed benign criteria, suspicious criteria or unsatisfactory criteria by FNAB with diploid DNA. Before surgery, these patients were made euthyroid by supplementing thyroxin or by treatment with anti-thyroid drugs.

Malignancy in solitary thyroid nodule: A clinicoradiopathological evaluation

Central node dissection was done in 22 6 positive patients, left side modified neck dissection MND in soliitary 3 positive patients, right side MND in 2 1 positive patients, bilateral MND in 3 patients 2 positiveleft MND and central nodal dissection was performed in 2 1 Positive patient [ Table 2 ].

During surgery, the site and type of incision were decided.


solitary thyroid nodule thesis

soltiary In all other cases, hemi thyroidectomy was done and subsequent plan was decided based on conclusive frozen or paraffin section report.

For the cystic nodules, aspiration is both diagnostic and curative, with post aspiration observation. Indian J Endocrinol Metab. In these ten patients frozen or paraffin section was reported as malignant. Contemporary Management of Solitary Thyroid Nodule. Hypocalcemic features were managed with supplementation of calcium and Vitamin D. The difference in age and sex among the different types of malignancy is non significant.

solitary thyroid nodule thesis

The goal of the evaluation of the thyroid nodule is to identify and surgically treat patients with malignancies, while identifying and avoiding surgery in those with benign, asymptomatic thyroid nodules.

Subtotal operations are followed by I-ablation therapy. It included all the patients with clinically detected STN who had undergone thyroidectomy between June and May All the patients who presented to the outpatient department with a clinically detected STN were included in the study group.

Author: Moustafa Elnahas,Waleed/ Title: Contemporary Management of Solitary Thyroid Nodule

Patients with aneuploid differentiated thyroid tumors have poorer prognosis compared with patients with diploid tumors. DNA aneuploidy was theeis to be more common in patients with thyroid carcinoma. New criteria for surgery.